The Effect of Water Carbonation on Orthostatic Tolerance
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-50
SponsorSimon Fraser University
About this trial
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers. Orthostatic tolerance refers to the ability to maintain an adequate blood pressure when standing. In some individuals blood pressure can fall when standing, predisposing to dizzy spells or fainting episodes. Drinking water can boost blood pressure and making fainting episodes less likely. However, it is not clear whether the carbonation of the water has any further impact on the blood pressure response. This is important because it may be that carbonated water expands the stomach (gastric distension), provoking an increase in sympathetic activity. The increase in sympathetic nervous system activity boosts blood pressure. Resolving this question would have important implications for patients with syncope. This study will test whether carbonated water will have any further impact on blood pressure than the already known effect of non-carbonated water.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
healthy, English-speaking
Disqualifiers
pregnancy or suspected pregnancy, history of cardiovascular disease, history of neurological disease, history of recurrent fainting (≥ 2 episodes of fainting with loss of consciousness in the prior 6 months)
Trial design
Design model
Crossover
Treatments tested in this trial
500mL carbonated water
Other interventionDrink 500mL carbonated water immediately prior to head-up tilt test
500mL still water
Other interventionDrink 500mL still water immediately prior to head-up tilt test
50mL still water
Other interventionDrink 50mL still water immediately prior to head-up tilt test
Treatment groups
25 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Group A: 500mL carbonated water first, then 500mL of still water, then 50mL of still waterExperimental treatment 3 interventions
Group B: 500mL still water first, then 500 mL carbonated water, then 50mL still waterExperimental treatment 3 interventions
Group C: 500mL carbonated water first, then 50mL of still water, then 500mL of still waterExperimental treatment 3 interventions
Group D: 500mL still water first, then 50mL still water, then 500 mL carbonated waterExperimental treatment 3 interventions
Group E: 50mL still water first, then 500mL still water, then 500 mL carbonated waterExperimental treatment 3 interventions
Group F: 50mL still water first, then 500mL carbonated water, then 500 mL still waterExperimental treatment 3 interventions
Trial outcomes
Primary outcomes
1
Orthostatic tolerance
The time, in minutes, to presyncope (near-fainting) after the initiation of head-up tilt
Time frame
0-50 minutesSponsors and contacts
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Source ClinicalTrials.gov