Health TrialsbyHealthPanel

The Effects of Almond on Facial Skin Collagen and Wrinkles

ConditionsCollagen DegenerationWrinklePigmentationElastic Skin
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age35-70
SponsorIntegrative Skin Science and Research

About this trial

Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Subjects 35 to 70 years of age of all skin types

50% of the subjects will be postmenopausal women determined as >1-year loss of menstrual period

50% of the subjects will be premenopausal women

BMI 18.5 - 35 kg/m2

Disqualifiers

Those with a nut allergy

Those who are unwilling to discontinue oral collagen supplementation 1 month prior to the start of the study

Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention.

Individuals who are pregnant or breastfeeding

Trial design

Design model

Parallel

Treatments tested in this trial

  • Food: whole almonds

    Other intervention

    60 grams or (\~2 oz) will be consumed 5 times per week.

  • Food: non-nut snack

    Other intervention

    Protein and calorie matched non-nut-based food will be consumed 5 times per week by mouth

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: AlmondsExperimental treatment 1 intervention
Group B: Control SnackPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Skin collagen and elastin quantification

Assess with biopsy based histological examination

Time frame
24 weeks
2

Facial wrinkles

Wrinkle severity score measured by Facial Image Analysis System (BTBP 3D image analysis system). Higher scores indicate worsened wrinkle severity and lower scores represent improvement in wrinkle severity.

Time frame
24 weeks

Secondary outcomes

1

Pigment intensity score

Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation.

Time frame
12 Weeks
2

Pigment intensity score

Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation.

Time frame
24 Weeks
3

Expression of enzymes that either degrade collagen (MMP1) or inhibit collagen degradation (TIMP1) on skin biopsies

Assess through biopsy based histological examination

Time frame
24 Weeks
4

Plasma for potential AGE (advanced glycation end products) analysis

Blood samples will be collected

Time frame
12 Weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Integrative Skin Science and Research

Lead sponsor

Source ClinicalTrials.gov
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