Health TrialsbyHealthPanel

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

ConditionsInsulin ResistanceImpaired Glucose ToleranceObesityMetabolic Disturbance
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorUniversity of New Hampshire

About this trial

This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are:

1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18-30 years of age

Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (>2 days/week).

Fair cardiorespiratory fitness levels (Men: VO2>38.4 ml/kg/min; Women: VO2>32.6 ml/kg/min).

Disqualifiers

Hypertension (resting or diagnosed)

Impaired fasting blood glucose (>100mg/dL)

Diagnosed cardiovascular disease

Diagnosed diabetes

Trial design

Design model

Parallel

Treatments tested in this trial

  • Low Physical Activity and Added Carbohydrate Group

    Behavioral

    Young men and women will transition into a low physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group. One of the control groups will undergo a low physical activity intervention.

  • Low physical Activity Control

    Behavioral

    Young men and women will transition into a low physically active lifestyle for 10 days.

  • High Physical Activity and Added Carbohydrate Group

    Behavioral

    Young men and women will transition into a high physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group.

Treatment groups

45 Participants
are divided into 4 treatment groups
Group A: Low Physical Activity and Added Carbohydrate GroupExperimental treatment 1 intervention
Group B: Low Physical Activity ControlPlacebo comparator 1 intervention
Group C: Normal Activity ControlNo intervention 0 interventions
Group D: High Physical Activity and Added Carbohydrate GroupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

To determine if low physical activity alone contributes to insulin resistance in healthy, recreationally active young men and women compared to men and women that reduce their physical activity and consume added sugar-sweetened beverages.

We will use HOMA-IR to measure changes in insulin resistance across the 4 study groups

Time frame
10 days
2

To determine if the combined low physical activity and added carbohydrates impairs 24-hour glucose regulation compared the other study interventions.

Compare 24-hour glucose regulation (mmol/L) measurements across the four study groups

Time frame
10 days
3

To determine if fat oxidation is impaired when participants reduce their physical activity levels and consume added carbohydrates compared to the three interventions

Compare the change in fat oxidation after the 10 day intervention

Time frame
10 days

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of New Hampshire

Lead sponsor

Source ClinicalTrials.gov
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