The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy

ConditionsPOCD - Postoperative Cognitive Dysfunction Recovery Time Postoperative Neurocognitive Disorder Postoperative Delirium Bariatric Sleeve Gastrectomy Delayed Neurocognitive Recovery Total Intravenous Anesthesia Inhalational Anesthesia Cognitive Functions

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-65

SponsorSehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital

About this trial

In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.

The anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.

Studies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.

In this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

In a population of patient group who will undergo sleeve gastrectomy as bariatric surgery under general anesthesia in Sancaktepe Sehit Prof. Dr. Ilhan Varank Research and Training Hospital in Istanbul and who have passed the multidisciplinary council for bariatric surgery.

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

60 Participants

are grouped into 2 trial groups

Group A: "Total Intravenous Anesthesia"

Group B: "Inhalational Anesthesia"

Trial outcomes

Primary outcomes

detecting postoperative delirium, delayed neurocognitive recovery and POCD (postoperative neurocognitive disorder)

Primary Outcome Measure 1: Time to Eye Opening After Cessation of Anesthetics The time from discontinuation of anesthetic agents to spontaneous eye opening in response to verbal stimulation will be recorded. Time Frame: From cessation of anesthetic agents until eye opening at the end of surgery. Primary Outcome Measure 2: Time to Obey Verbal Commands After Cessation of Anesthetics The time from discontinuation of anesthetic agents until the patient obeys simple verbal commands will be recorded. Time Frame: From cessation of anesthetic agents until obeying verbal commands at the end of surgery. Primary Outcome Measure 3: Time to Extubation The time from discontinuation of anesthetic agents until successful tracheal extubation will be recorded. Time Frame: From cessation of anesthetic agents until extubation at the end of surgery. Primary Outcome Measure 4: Time to Reach Aldrete Recovery Score 9-10 The time required to achieve an Aldrete Recovery Score of 9-10 in the post-anes

Time frame

Mini Mental State Examination(MMSE) Score and Addenbrooke's Cognitive Examination(ACE) Score Preoperative baseline (1 day before surgery), postoperative 1st, 6th, 12th, and 24th hours, postoperative 3rd and 7th days, and postoperative 1st and 3rd months.

Secondary outcomes

Hypertension, hypotension, hypoxia, hypercarbia, brady/tachycardia, VAS (Visual Analogue Scale), nausea and vomiting, bleeding, fever, wound infection, pulmonary complications, length of stay in intensive care unit and hospital.

Any hypertension, hypotension, hypoxia, hypercarbia, brady/tachycardia that may develop during the patient's 1-hour follow-up in the recovery room will be noted, and pain status will be assessed with VAS, nausea-vomiting status and overall patient satisfaction will be assessed. In addition, conditions such as bleeding, fever, wound infection, pulmonary complications that may develop in the patient will be noted, and the length of stay in the intensive care unit and hospital will be recorded.

Time frame

1 hour in the recovery room.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital

Lead sponsor

Source ClinicalTrials.gov

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