The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBeijing Tiantan Hospital
About this trial
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosed as unilateral supratentorial glioma by MRI
Selective operation
Age over 18 years old
ASA I-II
Disqualifiers
History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
History of intracranial surgery
Drug and/or alcohol abuse
History of dementia or mental illness
Trial population
The population will be selected from patients who schedule to receive elective surgery in Beijing Tiantan Hospital.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Dexmedetomidine
DrugParticipants will be sedated and maintained by dexmedetomidine during the surgery.
Propofol
DrugParticipants will be sedated and maintained by propofol during the surgery.
Remimazolam Injection
DrugParticipants will be sedated and maintained by remimazolam during the surgery.
Treatment groups
120 Participants
are divided into 3 treatment groupsGroup A: Dex group1 intervention
Group B: Propofol group1 intervention
Group C: Remimazolam group1 intervention
Trial outcomes
Primary outcomes
1
The alterations of brain network connectivity.
fMRI and DTI will be used to detect brain network connectivity.
Time frame
Before sedation, 30 minutes after sedation，and 30 minutes after surgery.Secondary outcomes
1
Postoperative delirium.
The incidence and severity of postoperative delirium and its association with changes of brain network connectivity.
Time frame
Day 1-5 after surgery.2
Electroencephalogram changes
Electroencephalogram will be used to record the brain activity.
Time frame
From patients admission to operation room until 10 minutes after surgery3
rScO2 changes.
Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS).
Time frame
From patients admission to operation room until 10 minutes after surgerySponsors and contacts
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Source ClinicalTrials.gov