The Effects of Ceylon Cinnamon (Cinnamomum Verum) Supplementation on Blood Glucose, Lipid Profile Levels, Body Mass Index, and Pain Intensity Among Adult Individuals With Painful Diabetic Peripheral Neuropathy

ConditionPainful Diabetic Peripheral Neuropathy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorJAWAD AHMAD ABU-SHENNAR

About this trial

Background: Painful diabetic peripheral neuropathy (PDPN) is a severe, disabling complication of type 2 diabetes mellitus (T2DM), closely associated with insulin resistance, chronic neuroinflammation, and oxidative stress. Plant-based dietary supplements, particularly Ceylon cinnamon (Cinnamomum verum), contain bioactive compounds with potential anti-diabetic, antioxidant, and neuroprotective properties.

Aim: To evaluate the effects of Ceylon Cinnamon (Cinnamomum verum) supplementation on blood glucose, lipid profile levels, body mass index (BMI), and pain intensity among adult individuals with painful diabetic peripheral neuropathy (PDPN).

Methods: A prospective, double-blind, randomized controlled trial (Double-Blind RCT) was conducted (Feb-July 2026) across endocrinology outpatient clinics in Jordan. Participants were randomly allocated in a 1:1 ratio to either the Intervention Group (n = 62; 500 mg Ceylon cinnamon twice daily for 6 months alongside standard care) or the Placebo Control Group (n = 62; 500 mg placebo capsules twice daily for 6 months alongside standard care). Clinical, biochemical, and pain assessments (using the Numeric Rating Scale \[NRS\]) were evaluated at baseline, 3 months, and 6 months post-intervention.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18years diagnosed with PDPN

With documented T2DM

Disqualifiers

If they had coexisting chronic conditions, including chronic kidney disease (CKD), hypertension, cardiovascular disease (CVD), or cognitive/sensory impairments (e.g., reading or hearing difficulties).

individuals receiving medications that could confound blood glucose control or pain perception (such as systemic glucocorticoids, weight-loss agents, or iron and vitamin B12 supplements)

Trial design

Design model

Parallel

Treatments tested in this trial

Ceylon Cinnamon Supplement
Dietary supplement
500 mg Ceylon cinnamon twice daily for 6 months

Treatment groups

164 Participants

are divided into 2 treatment groups

Group A: Ceylon Cinnamon GroupExperimental treatment 1 intervention

Group B: Control GroupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Change in Pain Intensity

Measured using a validated scale (such as the Visual Analog Scale - VAS or Numeric Rating Scale - NRS) to assess changes in neuropathic pain severity among participants.

Time frame

Baseline and at the end of the intervention period ( 6 months).

Secondary outcomes

Change in Blood Glucose Levels

Assessment of fasting blood glucose or HbA1c levels.

Time frame

Baseline and at the end of the intervention period ( 6 months).

Other outcomes

Change in Lipid Profile Levels

Assessment of serum lipids, including total cholesterol, triglycerides, LDL, and HDL.

Time frame

Baseline and at the end of the intervention period ( 6 months).

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

JAWAD AHMAD ABU-SHENNAR

Lead sponsor

Jerash Private University

Sponsor institution

Source ClinicalTrials.gov

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