In this study, patients with infertility treated with IVF at the Center of Reproductive Medicine in Linköping, Sweden, will receive recipes and food according to Nordic dietary guidelines. The purpose is to investigate whether a short diet intervention is sufficient to improve sperm quality and shift the small non-coding RNA profile. In our previous study sperm showed rapid response to diet.
Male (biological) partner in infertile couple, scheduled for first IVF treatment
Mature sperm cells in semen
Able to speak and read Swedish
Omnivore
Former or present malignant disease
Former radiotherapy in pelvic area
Former chemotherapy
Known genetic/chromosomal disorder
Parallel
Diet intervention NMR
Dietary supplementParticipants will receive groceries to their homes with planned recipes. The recipes are planned by using the Nordic nutrition councils recommendations.
Sperm RNA profile changes
Small RNA profiling and sequencing will be performed on sperm cells provided by participant at the start of controlled ovarian hormone stimulation of partner and at time of ovum pick-up and compared between the intervention groups.
Sperm total count
Sperm total count in millions, assessed by sperm analysis
Sperm concentration
Sperm concentration assessed by sperm analysis in millions/ml, with total sperm count in millions, divided by semen volume assessed in ml.
Sperm sample analysis
Sperm motility assessed, proportion of motile sperm to total amount of sperm, reported in percent
Fertilization rate
Number of normally fertilised oocytes, assessed as proportion of total number of oocytes retrieved (percent)
High quality embryo rate
Number of high quality embryo in relation to total number of oocytes fertilised
Embryos frozen
Number of good quality embryos frozen
Clinical pregnancy rate
Defined by viable intra-uterine pregnancy at ultrasonography in gestational week 7-9
Oxidative stress in sperm sample
Reactive oxygen species analysis of semen
Click on the lead sponsor to view all of their trials.
Ostergotland County Council, Sweden
Lead sponsor
Region Östergötland
Sponsor institution
