Health TrialsbyHealthPanel

The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers

ConditionAge-related Functional Decline
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorNational Yang Ming Chiao Tung University

About this trial

This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

aged ≥ 65 years

slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women)

Disqualifiers

established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions

active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on

estimated life expectancy <12 months

current nursing home residents

Trial design

Design model

Parallel

Treatments tested in this trial

  • Multi-domain intervention

    Behavioral

    Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Multidomain intervention groupExperimental treatment 1 intervention
Group B: Usual care groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Change in Physical performance

Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants

Time frame
baseline, 6 month

Secondary outcomes

1

Change in DHEA-S

Change in DHEA-S concentration from baseline to 6 months in all participants

Time frame
baseline, 6 month
2

Change in IGF-1

Change in IGF-1 concentration from baseline to 6 months in all participants

Time frame
baseline, 6 month
3

Change in hs-CRP

Change in hs-CRP concentration from baseline to 6 months in all participants

Time frame
baseline, 6 month
4

Change in Myostatin

Change in Myostatin concentration from baseline to 6 months in all participants

Time frame
baseline, 6 month

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National Yang Ming Chiao Tung University

Lead sponsor

National Health Research Institutes, Taiwan

Collaborator

Source ClinicalTrials.gov
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