The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorIntegrative Skin Science and Research
About this trial
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
Individuals with facial fine lines and wrinkles
Disqualifiers
Individuals who are pregnant or breastfeeding
Prisoners
Adults unable to consent
Those with a nut allergy or tocopherol allergy
Trial design
Design model
Parallel
Treatments tested in this trial
Topical Product: Almond Oil
Other intervention1-2 Drops of randomized topical product will be applied on entire face nightly.
Topical Product: Almond oil augmented with 0.5% Vitamin E
Other intervention1-2 Drops of randomized topical product will be applied on entire face nightly.
Topical Product: 0.025% Tretinoin oil augmented with castor oil
Other intervention1-2 Drops of randomized topical product will be applied on entire face nightly.
Treatment groups
90 Participants
are divided into 3 treatment groupsGroup A: Almond OilExperimental treatment 1 intervention
Group B: Almond oil augmented with 0.5% Vitamin EExperimental treatment 1 intervention
Group C: 0.025% Tretinoin oil augmented with castor oilExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Facial wrinkles
Change in severity of wrinkles measured by photographic analysis (BTBP 3D Camera System)
Time frame
16 WeeksSecondary outcomes
1
Changes in Pigment intensity through the use of high resolution photography (BTBP Clarity Pro)
Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation.
Time frame
16 Weeks2
Pigment intensity measured through SkinColorCatch.
Change in the appearance of facial pigmentation will be measured on both cheeks through the use of a handheld device known as the SkinColorCatch with quantitative output for pigment intensity.
Time frame
16 Weeks3
Changes in skin hydration
Change in skin hydration will be measured on both cheeks through the use of a non-invasive device known as the Moisturemeter.
Time frame
16 Weeks4
Sebum excretion rate
Measure of skin sebum via sebumeter
Time frame
16 WeeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov