The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Chronic Ankle Instability

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorBahçeşehir University

About this trial

Chronic ankle instability (CAI) is a common condition after lateral ankle sprain. CAI is characterized by mechanical and/or functional instability, or recurrent episodes of "giving way," persisting for at least 12 months after the initial injury, and is associated with limitations in activity and participation. In amateur athletes, CAI may be overlooked or undertreated, although sport-specific activities require rapid integration of visual, vestibular, somatosensory, and cognitive information.

Postural stabilization training is commonly used to improve balance and neuromuscular control in individuals with CAI. However, individuals with CAI may show increased reliance on visual information and altered visual-vestibular sensory reweighting during postural control tasks. The vestibulo-ocular reflex (VOR) contributes to gaze stability and visual clarity during head movements and may also be related to neurocognitive processes such as attention and processing speed. This study is designed as a randomized controlled, prospective, parallel-group, pretest-posttest design trial to investigate whether VOR exercises added to postural stabilization training improve dynamic balance, functional instability, and neurocognitive performance in amateur athletes with CAI.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Being between 18 and 35 years of age.

Being classified as a Tier 2 athlete according to the McKay et al. Participant Classification Framework (trained/developmental level).

Having a history of at least one lateral ankle sprain (LAS) occurring at least 12 months before enrollment, resulting in swelling, pain, and functional impairment, and followed by persistent instability.

Having the most recent ankle sprain at least 3 months before study enrollment.

Disqualifiers

History of acute lateral ankle sprain within the last 3 months.

History of lower extremity surgery.

History of acute injury to other musculoskeletal structures of the lower extremity joints within the last 3 months that affected joint integrity and function and caused interruption of desired physical activity for at least one day.

History of balance or vestibular disorders, including cerebellar, vestibular, cochlear, or inner ear dysfunction.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Postural Stabilization Training

    Other intervention

    Participants in this group will receive ankle joint mobilization followed by a structured postural stabilization training program. The program will include single-leg stance progression, hop stabilization tasks, and number-sequence hop tasks. Exercises will be progressed according to the participant's ability to complete each task without errors. Ankle joint mobilization will include talocrural anteroposterior mobilization and distal fibular mobilization with movement, applied before the exercise session for approximately 5 minutes. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.

  • Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training

    Other intervention

    Participants in this group will receive the same ankle joint mobilization and postural stabilization training program as the Postural Stabilization Training Group. In addition, vestibulo-ocular reflex (VOR) exercises involving fixation on a visual target during head movements will be implemented. VOR exercises will be structured to progressively increase postural demands and will include sitting, standing, walking, and single-leg stance positions. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.

Treatment groups

56 Participants
are divided into 2 treatment groups
Group A: Postural Stabilization Training GroupActive comparator 1 intervention
Group B: Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training GroupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Y Balance Test

The Y-Balance Test will be used to assess dynamic postural control. Participants will perform the test barefoot, standing on the test limb with hands on the hips, and will reach in the anterior, posteromedial, and posterolateral directions with the free limb. Invalid trials, including loss of balance, movement of the stance foot, or removal of the hands from the hips, will be repeated. Reach distances will be recorded in centimeters, normalized to limb length, and a composite score will be calculated.

Time frame
baseline, 6 weeks after baseline, and 10-week after baseline

Secondary outcomes

1

Cumberland Ankle Instability Tool

The Cumberland Ankle Instability Tool is a 9-item questionnaire used to evaluate perceived ankle instability and functional limitations. The total score ranges from 0 to 30, with lower scores indicating greater ankle instability. A score of 24 or lower is considered consistent with functional ankle instability

Time frame
baseline, 6 weeks after baseline, and 10-week after baseline
2

Single-Leg Stance + Number / Word Sequence Task

This task will assess static balance under cognitive load. Participants will stand on the affected limb on a foam pad and perform a backward number or word sequence task. In the first 10 seconds, the researcher will read six random items; participants must repeat them in reverse order within the next 10 seconds while maintaining balance. Each trial will last 20 seconds. Postural errors include removing hands from the hips, touching the ground with the non-stance foot, moving or hopping on the stance foot, hip flexion or abduction \>30°, limb contact, loss of balance, or failure to maintain the position for \>5 seconds. Each error scores 1 point, up to 10 per trial. One cognitive error is recorded for incorrect order, incomplete recall, or no response within 10 seconds. The total score is the sum of postural and cognitive errors; higher scores indicate poorer performance. After one practice trial, three trials will be recorded, and the mean total error score will be used for analysis.

Time frame
baseline, 6 weeks after baseline, and 10-week after baseline
3

Side Hop Test + Pinhole Glasses

This test will assess hopping performance under visual constraint. Participants will stand on the affected limb and hop laterally and medially over two parallel lines placed 30 cm apart. Before testing, they will complete 3-4 submaximal practice repetitions without visual constraint. During testing, participants will wear pinhole glasses and complete the task as quickly as possible. One repetition is defined as hopping from the outside of one line to the outside of the opposite line and back to the starting side. The time required to complete 10 round-trip hops will be recorded in seconds. Two trials will be performed with a 60-second rest interval, and the shortest time will be used for analysis. A trial will be repeated if the contralateral limb touches the ground, the participant steps on a line, double-limb contact occurs, or the hopping sequence is interrupted.

Time frame
baseline, 6 weeks after baseline, and 10-week after baseline
4

Figure-of-Eight Hop Test + Backward Counting Task

The Figure-of-Eight Hop Test with backward counting will assess hopping performance under cognitive load. Participants will hop on the affected limb around two cones placed 5 m apart, completing the figure-of-eight pattern twice as quickly as possible. Before testing, they will walk through the course and complete one submaximal hopping trial without the cognitive task. During testing, participants will count backward by sevens from a number between 200 and 250; numbers ending in 7 or 0 will be excluded. They will perform both tasks simultaneously without prioritizing either. After a cognitive error, the researcher will provide the correct response and the participant will continue. A trial will be repeated after contralateral foot contact, double-limb contact, cone contact or displacement, course deviation, pattern disruption, or balance loss. Two trials will be performed with 60-s rest. The shortest completion time and number of correct cognitive responses will be recorded.

Time frame
baseline, 6 weeks after baseline, and 10-week after baseline

Other outcomes

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