Health TrialsbyHealthPanel

The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD

ConditionsParkinson DiseaseOlfactory DisorderOlfactory Training
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-75
SponsorAnhui Medical University

About this trial

To explore the efficacy of olfactory training on olfactory and other non-motor symptoms in PD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

PD was diagnosed according to the criteria of Movement Disorders and Parkinson Disease Group of Chinese Society of Neurology of Chinese Medical Association.

Olfactory score was 1 standard deviation lower than the corresponding age norm;

no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability;

Disqualifiers

Parkinson's syndrome and Parkinson's plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.;

Neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.;

History of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. Upper respiratory tract infection in the past 3 weeks;

Long-term smoking and occupations that inhale chemical irritants for a long time.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Olfactory training

    Device

    Olfactory training used repeated stimulation of different olfactory substances at high concentrations, combined with odor association and odor identification training, twice in the morning and evening, each time for 5 minutes, for 15 weeks.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: OT grroupExperimental treatment 1 intervention
Group B: No intervention groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Olfactory Function Test

The olfactory test developed by the Institute of Psychology, Chinese Academy of Sciences was used to evaluate the olfactory ability, including threshold, discrimination, and recognition.

Time frame
baseline;15 weeks

Secondary outcomes

1

MoCA

Time frame
baseline;15 weeks
2

Pittsburgh sleep quality index

Time frame
baseline;15 week
3

HAMA

Time frame
baseline;15week
4

HAMD

Time frame
baseline;15 week

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Anhui Medical University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: