This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
Adults 18-75 years old
Normal kidney function
No heart failure
BMI 25-30kg/m2
Diagnosis of chronic illness
eGFR<60mL/min/1.73m2
Pregnancy or breast feeding
History of cutaneous or allergic reaction to iodine-based products of contrast dyes
Community-dwelling ambulatory participants who have HFpEF and obesity. We will compare with health participants and participants with obesity but without HFpEF.
Cohort
Prospective
High protein and sodium meal
Other interventionMeal with 1g/kg protein content and 3900mg sodium
Change in measured GFR
Change in urine sodium excretion
Click on the lead sponsor to view all of their trials.
