Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders (such as sickle cell disease), white blood cell disorders, and disorders of the blood clotting factors found in plasma.
Blood platelets are small cell fragments that help people stop bleeding after blood vessels are damaged. Some individuals have abnormalities in their blood platelets that result in them not functioning properly. One such disorder is Glanzmann thrombasthenia. Most such patients have a bleeding disorder characterized by nosebleeds, gum bleeding, easy bruising (black and blue marks), heavy menstrual periods in women, and excessive bleeding after surgery or trauma. Our laboratory performs advanced tests of platelet function and platelet biochemistry. If we find evidence that a genetic disorder may be responsible, we analyze the genetic material (DNA and RNA) from the volunteer, and when possible, close family members to identify the precise defect.
Normal healthy volunteers
18 years of age or older
Either sex
Any ethnic background.
For studies of platelets that may be affected by anti-platelet therapy, ingestion of aspirin or similar medication in the past week.
Having given blood in the last 8 weeks such that the current donation would exceed a total of 250 ml for the 8 week period.
Having given blood in the past week such that this donation would result in more than 2 donations in one week.
For studies of platelets that may be affected by antiplatelet therapy, ingestion of aspirin or similar medication in the past week
For normal volunteers, we recruit from laboratory personnel and other volunteers from the NYC area. Patients with platelet disorders, coagulation disorders, or white blood cell disorders, are recruited from among patients referred by other physicians to the P.I. for assessment or via the internet.
Case-control
Prospective
Not listed
Platelet aggregation
The initial slope of the increase in light transmission after an agonist is added to a cuvette containing platelet-rich plasma.
Click on the lead sponsor to view all of their trials.
Rockefeller University
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
