The Harefield Acute Myocardial Infarction Cohort

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorRoyal Brompton & Harefield NHS Foundation Trust

About this trial

In this project the investigator's plan to collect blood during a patient's routine angiogram procedure which they will have due to having suffered a heart attack. Data from the patients' routine procedures for this condition, including but not exclusively, ECG, Echocardiogram, MRI scans, will be collected. The aim of the research project is to analyse the blood samples and identify novel biomarkers and clinical parameters associated with acute coronary syndromes. The investigator's will particularly focus on markers of inflammation and micro-organism activity. The investigator's hope that this will help to gain more knowledge about what causes heart disease and how various conditions can be treated more efficiently. The investigator's will follow-up and collect further research data via a questionnaire at the routine 6 weeks and 6 months follow-up appointment after the angiogram procedure. Participants will also be telephoned at one-year post procedure, to update any events and medication status and data will thereafter be collected form data held by the hospital without having to contact the participant. Remaining blood samples will be stored securely for further analysis into blood and other markers.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Patients will be able to self-exclude if they do not provide full informed consent

Every effort will be made to obtain informed consent from all patients.

Patients who do not survive the hospital episode will undergo a Professional or Personal Consultee process of assumed consent.

Trial population

All patients presenting to Harefield Hospital through the Primary Percutaneous Coronary Intervention programme

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • 60mls of blood donated for research analysis

    Other intervention

    All patients presenting with a possible Acute Coronary Syndrome will be invited to donate 60 mls of blood at the time of their angiogram.

Treatment groups

2,000 Participants
are divided into 2 treatment groups
Group A: Acute Coronary Syndrome - Iscaemia1 intervention
Group B: Acute Coronary Syndrome - Non-Ischaemic1 intervention

Trial outcomes

Primary outcomes

1

To identify novel biomarkers and clinical parameters associated with acute coronary syndromes caused by coronary artery disease

1. Inflammatory markers 2. Microbiome metabolites

Time frame
2 - 5 Years

Secondary outcomes

1

To define the patient population with Myocardial Infarction with Non-Obstructive Coronary Artery disease (MINOCA) and determine the individual risks of these patients (eg. TakoTsubo Syndrome and Acute Myocarditis).

To define the patient population with Myocardial Infarction with Non-Obstructive Coronary Artery disease (MINOCA) and determine the individual risks of these patients (eg. TakoTsubo Syndrome and Acute Myocarditis).

Time frame
2 - 5 Years
2

To explore the concept of personalised medicine for future patients, based on the identification of novel biomarkers.

To explore the concept of personalised medicine for future patients, based on the identification of novel biomarkers.

Time frame
2 - 5 Years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.