The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow

ConditionsTranscutaneous Electrical Nerve Stimulation (TENS)Popliteal Blood Flow Sympathetic Ganglia

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorKaohsiung Medical University

About this trial

This study aims to evaluate the immediate hemodynamic effects of transcutaneous electrical nerve stimulation (TENS) on the popliteal artery and vein. Vascular issues like PAOD and DVT are common in patients with diabetes, obesity, or immobility due to increased resistance and reduced blood flow. Traditional treatments (medication or surgery) are not always feasible, prompting interest in TENS as an alternative. Although primarily used for pain relief, TENS may enhance blood flow. This research compares different stimulation frequencies (80 Hz vs. 4 Hz) and sites (gastrocnemius muscle vs. thoracolumbar sympathetic ganglia) to identify the most effective configuration.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy people

Age: 18 years and above (inclusive)

Body mass index (BMI) between 18.5 and 24

Disqualifiers

Unable to complete two interventions within a week

Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss)

Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3

Trial design

Design model

Single group

Treatments tested in this trial

Transcutaneous Electrical Nerve Stimulation，TENS
Device
low frequency (4Hz) and sympathetic ganglion(T12.L1.L2) low frequency (4Hz) and gastrocnemius high frequency (80Hz) and sympathetic ganglion(T12.L1.L2) high frequency (80Hz) and gastrocnemius

Treatment groups

43 Participants

are divided into 4 treatment groups

Group A: Sympathetic Ganglia with Low-Frequency Electrical StimulationExperimental treatment 1 intervention

Group B: Sympathetic Ganglia with High-Frequency Electrical StimulationExperimental treatment 1 intervention

Group C: gastrocnemius with Low-Frequency Electrical StimulationExperimental treatment 1 intervention

Group D: gastrocnemius with high-Frequency Electrical StimulationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Doppler ultrasound measurement of changes in popliteal fossa blood flow

Using Doppler ultrasound to measure blood flow before, during, immediately after, and 15 minutes after electrical stimulation to observe the effects of electrical stimulation on blood flow.

Time frame

45 minutes

Secondary outcomes

heart rate

oximeter to measure heart rate before, during, immediately after, and 15 minutes after electrical stimulation to observe the effects of electrical stimulation on heart rate.

Time frame

45 minutes

Locations

Map coordinates are unavailable for these locations. Locations are shown below instead.

Kaohsiung Medical UniversityRecruiting807378, Kaohsiung City, Taiwan Taiwan

Taiwan

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kaohsiung Medical University

Lead sponsor

Source ClinicalTrials.gov

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