The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorMayo Clinic
About this trial
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
aged greater than or equal to 65 years
sedentary (Community Healthy Activities Model Program for Seniors physical activity questionnaire to identify and exclude persons engaged in regular (125 min/week or more) moderate intensity physical activity
at risk for mobility disability score of less than or equal to 10 (but greater than 3) on the SPPB
willing to be randomized into HE or PRT
Disqualifiers
unwillingness to provide informed consent
participation in lifestyle or pharmacologic intervention trial or structured program of exercise training in the past 6 months
an SPPB score of less than or equal to 3
osteoarthritis or condition with joint pain limiting daily life activities
Trial design
Design model
Parallel
Treatments tested in this trial
Progressive Resistance Training
Other intervention3 times a week
Health Education
Other interventiononce a week
Treatment groups
300 Participants
are divided into 2 treatment groupsGroup A: Progressive Resistance TrainingOther 1 intervention
Group B: Health EducationOther 1 intervention
Trial outcomes
Primary outcomes
1
Precisely define the variability in changes in physical function
Measured by the Short Physical Performance Battery (SPPB), a 0-12 categorical scale of walking speed, standing balance, and repeated sit-to-stand time, with higher scores reflecting better physical function.
Time frame
baseline, 6 months2
Precisely define the variability in changes in blood glucose concentrations in response to a meal tolerance test
Blood glucose concentrations (millimoles/liter) will be measured in response to a physiologically relevant meal challenge. Lower values are indicative of better metabolic health.
Time frame
baseline, 6 monthsSecondary outcomes
1
Precisely define the variability in changes in skeletal muscle size.
Measured by computed tomography scans of the mid-thigh. Larger muscle cross-sectional area (cm\^2) reflects a greater quantity of skeletal muscle.
Time frame
baseline, 6 months2
Precisely define the variability in changes in skeletal muscle strength.
Measured by the one-repetition maximum, in newtons, on a leg press device, with higher scores reflecting greater skeletal muscle strength.
Time frame
baseline, 6 months3
Precisely define the variability in changes in six-minute walk distance.
Measured by the distance (meters) walked in six minutes, with longer distances reflecting better physical function.
Time frame
baseline, 6 months4
Precisely define the variability in insulin secretion in response to a mixed meal tolerance test.
Blood insulin concentrations (pmol/L) will be measured in response to a physiologically relevant meal challenge. Insulin concentrations in a physiological range reflect better metabolic health, while low insulin concentrations can reflect an impaired insulin response and high insulin concentrations can reflect peripheral insulin resistance.
Time frame
baseline, 6 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Mayo Clinic
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Tufts University Jean Mayer USDA Human Nutrition Research Center on Aging
Collaborator
Source ClinicalTrials.gov