The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:
Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population?
Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels?
Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.
Adults ≥18 years with clinically diagnosed hypertension treated with medication [on a stable dose at least for 2 months]
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Those with baseline K ≥5.0 or K <3.0 mmol/L
Advanced kidney disease (eGFR <45 ml/min/1.73m2).
Those on potassium sparing diuretics (e.g., spironolactone)
Other medical conditions determined by physicians (e.g., heart failure treated with medication; life expectancy less than 12 months)
Johns Hopkins University
Lead sponsor
National Heart Foundation of Bangladesh
Collaborator
Vital Strategies
Collaborator