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The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males

ConditionHypoxia, Altitude
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age19-29
SponsorUniversity School of Physical Education, Krakow, Poland

About this trial

* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males. * Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.

Disqualifiers

changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Exercise and environmental conditions

    Other intervention

    Participants will engage in interval training and will reside and sleep at different altitudes for a period of 4 weeks. Aerobic and anaerobic capacity tests and an eccentric exercise test will be performed before and after the training intervention. Before and after the training program, somatic measurements will also be taken. Before and after the first and last workout, blood will be drawn for biochemical analysis.

Treatment groups

50 Participants
are divided into 4 treatment groups
Group A: Control groupNo intervention 0 interventions
Group B: LHTL (live high - train low)Experimental treatment 1 intervention
Group C: LLTH (live low - train high)Experimental treatment 1 intervention
Group D: LLTL (live low - train low)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Measurement of aerobic capacity (endurance)

Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)

Time frame
7 days before training and 7-10 days after the training. Training will last 4 weeks.
2

Measurement of anaerobic capacity

Measurement of maximal anaerobic power (Wingate Anaerobic Test)

Time frame
7 days before training and 7-10 days after the training. Training will last 4 weeks
3

Blood analysis

Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes).

Time frame
7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.
4

Somatic indices

Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\]

Time frame
7 days before training and 7-10 days after the training. Training will last 4 weeks.

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University School of Physical Education, Krakow, Poland

Lead sponsor

Ministry of Education and Science,Poland

Collaborator

Source ClinicalTrials.gov
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