The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNegovsky Reanimatology Research Institute

About this trial

Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.

Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.

Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.

The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18

Planned primary total knee replacement

Planned neuraxial anesthesia

Written informed consent

Disqualifiers

Urgent surgery

Planned revision total knee replacement

Known allergic reaction to anesthetics

Confirmed localized infection at the puncture sites

Trial design

Design model

Parallel

Treatments tested in this trial

  • Single-shot adductor canal block

    Procedure/Surgery

    Postoperative analgesia in this group will be carried out by a single-shot bolus of 20 ml Ropivacaine 0.5% in the region of the middle third of the adductor canal.

  • Continuous femoral nerve block

    Procedure/Surgery

    Postoperative analgesia in this group will be carried out by continuous infusion of local anesthetics through a catheter installed to the femoral nerve in the area of the femoral triangle. Ropivacaine 0.2% solution will be used for postoperative analgesia. Local anesthetic infusion rate is 4 ml/h to 10 ml/h.

Treatment groups

220 Participants
are divided into 2 treatment groups
Group A: Single-shot adductor canal blockExperimental treatment 1 intervention
Group B: Continuous femoral nerve blockActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Ambulation distance

Less meters means worse outcome

Time frame
postoperative day 1

Secondary outcomes

1

Ambulation distance

Less meters means worse outcome

Time frame
postoperative day 2
2

Timed up and go test

More seconds means worse outcome

Time frame
postoperative day 1
3

Timed up and go test

More seconds means worse outcome

Time frame
postoperative day 2
4

10 meters walk test

More seconds means worse outcome

Time frame
postoperative day 1

Other outcomes

1

intravascular local anesthetic injection

frequency of intravascular local anesthetic injection

Time frame
30 day
2

neuropathy after the procedure

frequency of neuropathy after the procedure

Time frame
30 day

Sponsors and contacts

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