The Incidence And Risk Factors Of Recurrent Febrile Seizures And Epilepsy Following Febrile Seizures
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-8
SponsorPham Ngoc Thach University of Medicine
About this trial
The goal of this observational study is to learn about the recurrence and development of epilepsy in children hospitalized with their first febrile seizures. The main questions it aims to answer are:
* What is the risk of recurrence after the first febrile seizure and what are the risk factors for recurrent febrile seizures in Vietnamese children? * What is the risk of developing epilepsy later in life and what are the risk factors for developing epilepsy in Vietnamese children who have had febrile seizures?
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children had a diagnosis of first febrile seizure based on the definition of the International League Against Epilepsy (ILAE) in 1993. That was a seizure occurring in childhood after one month of age associated with a febrile illness not caused by an infection of the central nervous system, without previous neonatal seizures or a previous unprovoked seizure, and not meeting the criteria for other acute symptomatic seizures. Fever is clinically a temperature of at least 38°C by any method as recorded either in the emergency department, outpatient clinics, or as noted in the medical history, as well as measured upon admission to the inpatient departments.
Patients were between 1 month and 8 years of age
Agreement from parents with written informed consent
Disqualifiers
Febrile paroxysmal events were atypical for seizures
Underlying neurological conditions that increase the likelihood of epilepsy
Unwillingness to return for follow-up
Trial population
All children, who had a diagnosis of first febrile seizure at discharge from the General Pediatric Department and Neurology Department of Children's Hospital 2
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
650 Participants
are grouped into 1 trial groupGroup A: Initial Febrile Seizures
Trial outcomes
Primary outcomes
1
The incidence and risk factors of the recurrence of febrile seizures
Following the initial interview, parents were contacted every three months to determine whether their child had experienced any further seizures and the circumstances under which they occurred. If a febrile seizure recurs or an afebrile seizure occurs, parents can report it immediately and directly to the investigator.
Time frame
2 years2
The incidence and risk factors of the epilepsy following febrile seizures
We considered a seizure unprovoked if there were no acute precipitating circumstances to which the seizure could reasonably be attributed. According to the ILAE practical clinical definition from 2014, epilepsy is characterized by having two unprovoked seizures that are more than 24 hours apart
Time frame
2 yearsSponsors and contacts
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Source ClinicalTrials.gov