The ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan. It involves multiple hospitals and rehabilitation centres across the country and aims to better understand how cardiac rehabilitation (CR) is delivered to patients recovering from heart conditions (coronary artery disease and/or heart failure). CR is a structured programme that includes exercise, lifestyle education, and psychological support, and is known to improve recovery, reduce future cardiac events, lower hospital readmissions, and enhance quality of life. Despite strong recommendations from international guidelines, not all eligible patients are referred to CR, and its delivery varies. This study collects real-world data to describe how CR programmes are implemented, evaluate whether patients meet recommended treatment targets (such as lower cholesterol in coronary patients or reduced heart-failure blood markers), assess patient outcomes, identify subgroups needing tailored care, and support improvements in cardiac care services in Italy. Adults who recently experienced a qualifying heart condition are enrolled and followed during their standard rehabilitation, without any changes to treatment. Data on medical history, risk factors, quality of life, functional capacity, and medication use are collected, with follow-up at 6 and 12 months. Participation involves no added risks, and personal health data are securely managed in accordance with EU GDPR regulations using the REDCap system. The study aims to enhance the quality, consistency, and equity of cardiac rehabilitation across the country.
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Consecutive adult patients (≥18 years) with coronary artery disease and/or heart failure who are referred to and admitted to cardiac rehabilitation following an acute event, according to national eligibility criteria for early post-acute referral. Patients are enrolled across approximately 23 Italian cardiology and rehabilitation centres participating in the ITACARE-P network, in inpatient, outpatient, or Complex Outpatient Macro-Activity (MAC) settings, reflecting routine real-world clinical practice. The population includes complex and often under-represented subgroups (e.g., older, frail, or cognitively impaired patients) who meet referral criteria and provide written informed consent.
Cohort
Prospective
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Proportion of Participants Achieving Condition-Specific Therapeutic Goals
This composite outcome measures the proportion of participants who achieve either of the following condition-specific goals: an LDL-C target of \<55 mg/dL in patients with Coronary Artery Disease (CAD), OR a ≥30% reduction from baseline in NT-proBNP (or BNP) levels in patients with Heart Failure (HF)
Incidence of major adverse cardiovascular events (MACE)
Composite of cardiovascular death, recurrent myocardial infarction, stroke, and hospital readmission.
Incidence of all-cause deaths
Describes the cumulative probability of all-cause death during the follow-up
Incidence of hospital readmission (all-cause and cardiovascular).
Describes the cumulative probability of hospital readmission for all causes during follow-up
Risk-factor control : Blood pressure control, glycaemic control (HbA1c), smoking cessation, and physical activity level.
Describes the change in relevant risk factors
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Fondazione Don Carlo Gnocchi ETS
Lead sponsor
Istituti Clinici Scientifici Maugeri SpA
Collaborator
ASST Crema
Collaborator
IRCCS Ospedale San Raffaele
Collaborator
IRCCS Fondazione Don Gnocchi-Firenze
Collaborator
Fondazione Don Gnocchi Parma
Collaborator
U.O.S. Riabilitazione Cardiologica Area Sud Azienda USL Toscana
Collaborator
S.O.D. Riabilitazione Cardiologica Azienda Ospedaliero Universitaria Careggi Firenze
Collaborator
UOSD Cardiologia Riabilitativa Azienda Ospedaliera San Giovanni-Addolorata
Collaborator
IRCCS Istituti clinici Maugeri, Istituto di Montescano
Collaborator
IRCCS Istituti clinici Maugeri, Istituto di Pavia
Collaborator
IRCCS Istituti clinici Maugeri, Istituto di Gattico-Veruno
Collaborator
Struttura complessa Riabilitazione Cardiologica
Collaborator
Casa di cura villa gemma
Collaborator
Cardiologia Riabilitativa Tagliacozzo
Collaborator
ASST Brianza
Collaborator
Riabilitazione del Cardiopatico
Collaborator
UOS Cardiologia Riabilitativa ULSS Serenissima
Collaborator
Ospedale Riabilitativo di Alta Specializzazione
Collaborator
Istituto clinico Maugeri Lumezzane
Collaborator
IRCCS Multimedica San Giuseppe, Milano
Collaborator
Fondazione Don Carlo Gnocchi Onlus, Centro S. Maria alla Pineta, Massa
Collaborator
Multimedica San Giuseppe Castellanza
Collaborator
