The Krill Ageing Muscle Mechanisms (KAMM) Study
ConditionSarcopenia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-90
SponsorUniversity of Glasgow
About this trial
This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil
Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).
Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.
Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
body mass index (BMI) </= 30 kg/m2
Age >/= 65 years
Capacity to consent
Living within the Glasgow area
Disqualifiers
Diabetes mellitus
Severe cardiovascular disease
Seizure disorders
Uncontrolled hypertension (>150/90mmHg)
Trial design
Design model
Parallel
Treatments tested in this trial
Vegetable oil
Dietary supplementmixed vegetable oil
Krill oil
Dietary supplementKrill oil
Treatment groups
80 Participants
are divided into 2 treatment groupsGroup A: Vegetable oilPlacebo comparator 1 intervention
Group B: Krill oilActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Grip strength
We will measure grip strength using a handgrip dynamometer, making 3 maximal contractions in each hand, with the dominant hand recorded. The highest grip strength will be used in analysis.
Time frame
Change from baseline to 24 weeks2
Neuromuscular junction transmission instability
We will assess peripheral motor unit (MU) characteristics in the vastus lateralis muscle using intramuscular electromyography
Time frame
Change from baseline to 24 weeks3
Gait speed
We will measure gait speed using a gaitrite connected mat during a 4 m walk test and the timed up and go test at usual speed.
Time frame
Change from baseline to 24 weeksSecondary outcomes
1
Knee extensor maximal torque
We will measure the muscle strength of the knee extensor muscles during a maximal voluntary contraction (MVC)
Time frame
Change from baseline to 24 weeks2
Vastus lateralis muscle cross sectional area
We will measure this using ultrasound
Time frame
Change from baseline to 24 weeks3
Vastus lateralis pennation angle
We will measure this using ultrasound
Time frame
Change from baseline to 24 weeks4
Vastus lateralis fascicle length
We will measure this using ultrasound
Time frame
Change from baseline to 24 weeksSponsors and contacts
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Source ClinicalTrials.gov