The Longitudinal Cohort of Cerebral Small Vessel Disease in Ruijin Hospital
ConditionCerebral Small Vessel Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRuijin Hospital
About this trial
The goal of this observational study is to learn about neuroimage and biomarkers in the cerebral small vessel disease. The main questions it aims to answer are:
* How does neurovascular coupling change during the progression of CSVD? * How is the pattern/mapping of alterations in CSVD biomarkers? Participants will be observed and visit the research center annually to perform multi-modal MRI, PET, neuropsychological tests, and blood tests.
Eligibility criteria
Qualifiers
Age ≥18 years.
White matter hyperintensities (WMH) with a total Fazekas score ≥2;
Fazekas score =1 with at least two vascular risk factors (hypertension, hyperlipidemia, diabetes mellitus, obesity, current smoking, or a history of vascular events other than stroke);
Fazekas score =1 accompanied by the presence of lacunes;
Disqualifiers
Acute ischemic stroke with a diffusion-weighted imaging (DWI) lesion >20 mm in diameter.
Acute intracerebral hemorrhage.
Acute subarachnoid hemorrhage, a history of aneurysmal subarachnoid hemorrhage or cerebrovascular malformation, or the presence of an untreated intracranial aneurysm >3 mm in diameter.
Previously diagnosed neurodegenerative disorders, such as Alzheimer's disease (AD) or Parkinson's disease (PD).
Trial design
Treatments tested in this trial
- Not listed
Trial groups
400 Participants
are grouped into 3 trial groupsSponsors and collaborators
Source ClinicalTrials.gov