Health TrialsbyHealthPanel

The Natural History of Hospitalized COVID-19 Patients

ConditionSars-CoV2
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Milano Bicocca

About this trial

This is an observational study. The aim is to describe the natural history and clinical evolution over time of hospitalized patients affected by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) infection, including the genetic pathology of the disease and improve therapeutic procedures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Clinical and / or radiological diagnosis of lung infection with COVID-19;

Positive test for SARS-CoV-2 infection.

Disqualifiers

None

Trial population

The patients enrolled in the study are all patients with clinical and microbiological diagnosis of COVID-19 infection hospitalized since February 23, 2020 at San Gerardo Hospital (ASST-Monza).

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Observational cohort study on the natural history of hospitalized SARS-COV-2 patients.

    Other intervention

    Describe the natural history and clinical evolution of hospitalized patients over time affected by SARS-COV-2 infection, understand the pathogenesis of the disease and improve the aids and therapeutic procedures.

Treatment groups

1,433 Participants
are divided into 1 treatment group
Group A: Covid19 infection related patients1 intervention

Trial outcomes

Primary outcomes

1

Covid19 infection clinical evolution

Description over time of hospitalized patients suffering from SARS-COV-2 infection to better understand the pathogenesis of the disease and improve the controls and therapeutic procedures.

Time frame
Until patient discharge from the hospital (approximately 1 year)

Secondary outcomes

1

Risk factors for intra-hospital mortality

Identify risk factors for intra-hospital mortality in hospital wards COVID + patients.

Time frame
Until patient discharge from the hospital (approximately 1 year)
2

The impact of a fragility index (IF)

Assess the impact of a fragility index (IF) on the clinical course of COVID + patients.

Time frame
Until patient discharge from the hospital (approximately 1 year)
3

Prognostic score

Build a prognostic score through which it is possible define a stratification that orients, according to the state of hospitalization, the therapeutic choices.

Time frame
Until patient discharge from the hospital (approximately 1 year).
4

The lung sequelae of SARS-COV-2 pneumonia

Differentiate the lung sequelae related to the evolution of viral damage from those of cheater / volutrauma connected to non-invasive (NIV-CPAP) or invasive (MV) ventilation methods.

Time frame
Until patient discharge from the hospital (approximately 1 year)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Milano Bicocca

Lead sponsor

Source ClinicalTrials.gov
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