The Placental Thickness and Pregnancy Outcomes in Placenta Previa Women

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-35
SponsorAssiut University

About this trial

Placenta previa is the placenta overlying the cervical os. Placenta previa is about 1 in 200 pregnancies. The risk factors are the increasing rate of cesarean section and previous uterine surgery. Placenta previa is associated with many adverse complications; the most serious one is related to maternal hemorrhage. The diagnosis of placenta previa is done by trans-abdominal and trans-vaginal ultrasonography, which can document the placental edge's relationship to the internal os. Placenta accreta spectrum disorder is defined when trophoblastic invades the myometrium. The Placenta accreta spectrum can be categorized as: placenta accreta, placenta increta, and placenta percreta.

The clinical utility of placental thickness is an area of ongoing research in placenta previa. Prior studies have demonstrated an association between mid-trimester placental thickness and placenta accreta spectrum. Despite the presence of many studies in characterizing placental thickness, most studies have focused primarily on the placental accreta spectrum lacking information about other fetal and maternal complications. Symptomatic (bleeding) placenta previa is associated with increased maternal and neonatal morbidity and mortality. In addition; the mechanism that involves bleeding is unclear. It is usually related to uterine contractions, cervical effacement, and dilation leading to separation of the placenta from the underlying decidua.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Pregnant women from 32-34 weeks.

Pregnant women with singleton pregnancy.

Women with placenta previa.

Placenta previa with minimal vaginal bleeding or haven't any vaginal bleeding.

Disqualifiers

Women with severe bleeding necessitate immediate delivery.

Women with confirmed fetal malformation.

If associated with abruptio placentae.

Women who will refuse to participate.

Trial design

Design model

Parallel

Treatments tested in this trial

  • ultrasound

    Other intervention

    The placenta thickness will be performed on transabdominal images obtained in a longitudinal plane. Three measurements will be performed at the thickest portion of the placenta. The average of these three measurements was used for statistical analysis. The cohorts will be classified into 1) thick placenta (\>4 cm) and average placenta (2-4 cm).

Treatment groups

140 Participants
are divided into 2 treatment groups
Group A: Normal placental thickness womenOther 1 intervention
Group B: High placental thickness womenOther 1 intervention

Trial outcomes

Primary outcomes

1

number of women with placenta accreta

Time frame
3 weeks

Secondary outcomes

Other outcomes

Sponsors and contacts

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