The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorNational Taiwan University Hospital

About this trial

"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.

Eligibility criteria

Qualifiers

age between 18 and 50

diagnosed with ASD from licensed mental health or medical professional based on DSM5

have social problems

motivated to participate in the treatment

Disqualifiers

history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases

visual impairment and/or hearing impairment

any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.

Trial design

Treatments tested in this trial

  • PEERS

Treatment groups

120 Participants
are divided into 2 treatment groups