The Predictive Value of MRI for Adult-type Diffuse Gliomas

ConditionGlioma

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorFirst Affiliated Hospital, Sun Yat-Sen University

About this trial

The goal of this observational study is to learn about the diagnostic value of preoperative MRI examination for adult-type diffuse gliomas. The main question it aims to answer is:

* Can preoperative MRI examination noninvasively predict genotype of gliomas? * Can preoperative MRI examination noninvasively predict the overall survival of gliomas? * Can preoperative MRI examination noninvasively predict Ki-67 proliferation status?

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

First diagnosis of glioma, with no preoperative radiotherapy or chemotherapy.

Underwent multiparametric MRI examination in our hospital before surgery.

Tumor resection or biopsy was performed within 3 weeks after MRI examination.

Pathological examination confirmed glioma.

Disqualifiers

Inability to cooperate during MRI examination, resulting in poor image quality that prevents image analysis.

Surgery or biopsy specimens were unqualified and could not be analyzed pathologically.

Trial population

Study Site and Population Study Site: The First Affiliated Hospital of Sun Yat-sen University; Patients with glioma

Trial design

Design model

Case-only

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants

are grouped into 1 trial group

Group A: Adult-type diffuse gliomas

Trial outcomes

Primary outcomes

A model for predicting glioma grade and the status of prognosis-related molecular mutations, constructed using multiparametric MRI

The prognosis-related molecular mutation status, such as IDH mutation, is classified as dichotomous data. Mutations, deletions, or amplifications are categorized into the positive group and are denoted as 1; the absence of mutation, deletion, or amplification is categorized into the negative group and is denoted as 0.

Time frame

Through study completion, an average of 7 years

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

First Affiliated Hospital, Sun Yat-Sen University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: