The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

ConditionSeptic Shock

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorAvicenna Military Hospital

About this trial

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Absence of central venous access.

Central venous access not positioned in the superior vena cava (e.g., femoral access).

Trial population

Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \[Sepsis 3 criteria\]

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

PvCO2-PaCO2/CaO2-CvO2 ratio
Diagnostic test
Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).

Treatment groups

30 Participants

are divided into 1 treatment group

Group A: Adult patients with septic shock.1 intervention

Trial outcomes

Primary outcomes

Prognostic value of PvCO2-PaCO2/Ca O2-CvO2 in patients with septic shock

The ability of PvCO2-PaCO2/Ca O2-CvO2 to predict mortality in patients with septic shock. These biological values will be measure using arterial and central venous blood gaz.

Time frame

From patient inclusion (baseilie = H0) then at H2, H6, H 12 and H24 (H = hours)

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Avicenna Military Hospital

Lead sponsor

Source ClinicalTrials.gov

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