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The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

ConditionsPostoperative Acute Kidney InjuryFrailty
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorLanyue Zhu

About this trial

The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

18 years old or above

Undergo non-cardiac surgery

Disqualifiers

At least one measurement of serum creatinine (SCr) was not conducted before and after the operation

End-stage renal disease (ESRD) that has received dialysis within the past year

Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)

Acute kidney injury occurred within 7 days before the operation

Trial population

Patients who underwent non-cardiac surgery at Zhongda Hospital Southeast University.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Frailty status

    Other intervention

    This was an observational study with no intervention measures. The exposure factor was the frailty status of the patients.

Treatment groups

1,000 Participants
are divided into 2 treatment groups
Group A: Frail group1 intervention
Group B: Non-frail group0 interventions

Trial outcomes

Primary outcomes

1

Postoperative acute kidney injury

Time frame
Within one week after the operation

Secondary outcomes

1

Intraoperative blood pressure

Time frame
During the operation
2

Postoperative extubation time

Time frame
Perioperative period
3

Postoperative complications

Time frame
Perioperative period
4

Hospital stays

Time frame
Perioperative period

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Lanyue Zhu

Lead sponsor

Zhongda Hospital

Sponsor institution

Source ClinicalTrials.gov
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