To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods.
If there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. ultimately analyze whether it is related to the expression of FOsB in laryngeal cancer tissue and adjacent tissues
laryngeal squamous cell carcinoma was diagnosed ,and biopsy was confirmed by two pathologists;
Primary tumor of Laryngeal ,and there was no distant metastasis;
Standard treatment such as surgery and Preliminarily-diagnosed parients;
full clinical and pathological data information and good follow-up;
Secondary cancer or cancer with distant metastasis;
Patients who have not seen a doctor for the first time or have received surgery or radiotherapy or chemotherapy in other hospitals;
Clinical and pathological data were missing and loss to follow-up;
Patients who abandoned treatment or standard treatment procedures has not been completed;
Researchers are Collecting 100 to 200 cases of laryngeal cancer patients who have been finally diagnosed and treated in research institution.
Other
Other
the expression negative in laryngeal cancer tissue
Other interventionResearcher will incorporate the positive expression of FOSB protein in laryngeal cancer tissues into the positive study group and vice versa into the negative study group by immunohistochemical methods!
the expression positive in laryngeal cancer tissue
Other interventionResearcher will incorporate the positive expression of FOSB protein in laryngeal cancer tissues into the positive study group and vice versa into the negative study group by immunohistochemical methods!
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined.
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined by immunohistochemical test of pathological sections.
_Experimental result of western blot and PCR._Correlation analysis data between clinical information and experimental results..
Researcher will verify the effection of FosB gene on the proliferation and migration of Hep-2 laryngeal cancer cells through a series of basic experiments,such as Immunohistochemistry,western blot,PCR,and so on.clinical prognoostic information of patients was collected and the relationship with fosb gene expression was analyzed.
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Yang ji
Lead sponsor
Neijiang No.2 People's Hospital
Sponsor institution
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