The ROAR Study: Reactive Oxygen Species and Reproduction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-43
SponsorUniversity of California, San Francisco
About this trial
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Female age 18-43 years
Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
Male partners 18 years of age or older.
Must be a registered patient at UCSF Center for Reproductive Health
Disqualifiers
Female partner age 44 or older
Planning fresh transfer (hybrid PGS cycle)
Cleavage stage biopsy
Planning to use frozen sperm
Trial population
Heterosexual couples undergoing fresh IVF cycle
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Oxidative stress markers
Diagnostic testWe will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes
Treatment groups
1,100 Participants
are divided into 1 treatment groupGroup A: Couples undergoing IVF1 intervention
Trial outcomes
Primary outcomes
1
Implantation rate
Implantation rate of euploid embryos that result from a specific oxidative stress environment
Time frame
From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov