Health TrialsbyHealthPanel

The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis

ConditionsTuberculosisImmunologic Activity Alteration
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorLinkoeping University

About this trial

The goal of this observational study is to learn about how the blood leucocytes from patients with and without exposure or disease from tuberculosis (TB) are able to kill live mycobacteria (M. tuberculosis). The main question it aims to answer is:

Is intracellular growth suppression of M. tuberculosis in peripheral blood mononuclear cells variable among healthy blood donors and higher than in patients with latent TB compared to active TB?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

Subjects who are attending the infectious disease clinics at region Östergötland och region Kalmar, Sweden.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • No intervention.

    Other intervention

    Blood sampling for analysis of mycobacterial growth inhibition assay (MGIA) analysis.

Treatment groups

280 Participants
are divided into 4 treatment groups
Group A: Healthy Individuals1 intervention
Group B: Close contacts to patients with active TB1 intervention
Group C: Patients with (latent) tuberculosis infection1 intervention
Group D: Patients with active TB1 intervention

Trial outcomes

Primary outcomes

1

Mycobacterial inhibition of host macrophages

Mycobacterial inhibition of host macrophages

Time frame
Up to 10 days incubation
2

Mycobacterial inhibition of host peripheral blood mononuclear cells (PBMCs)

Mycobacterial inhibition of host peripheral blood mononuclear cells (PBMCs)

Time frame
Up to 10 days incubation

Secondary outcomes

1

Cytokine expression of host peripheral blood mononuclear cells (PBMCs)

Proteome analysis following exposure of PBMCs to gamma-irradiated M. tuberculosis

Time frame
24 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Linkoeping University

Lead sponsor

Source ClinicalTrials.gov
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