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The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults

ConditionHealthy Aging
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-80
SponsorUniversity of Nevada, Reno

About this trial

In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory/postural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age between 65 and 80 (elderly group) and between 20 and 35 (young group)

Disqualifiers

History of epilepsy, stroke, Parkinson's disease, Alzheimer's disease, attention deficit-hyperactivity disorder

History of head injury with loss of consciousness, brain surgery, or psychiatric disorders

Early dementia or cognitive impairment

Serious vision problems (including best-corrected binocular visual acuity worse than 20/25)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Inhibitory control training

    Behavioral

    Cognitive training is inhibitory task-related.

  • Knowledge-based training

    Behavioral

    Training is not inhibitory task-related.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Inhibitory control trainingExperimental treatment 1 intervention
Group B: knowledge-based trainingSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Multisensory temporal processing performance change

Change from pre-training performance

Time frame
At the end of 20-day training
2

Multisensory temporal processing performance change maintenance

Change from pre-training performance

Time frame
30 days after training
3

Postural control and gait performance change

Change from pre-training performance

Time frame
At the end of 20-day training
4

Postural control and gait performance change maintenance

Change from pre-training performance

Time frame
30 days after training

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Nevada, Reno

Lead sponsor

Source ClinicalTrials.gov

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