The Role of Gender in Borderline Personality Disorder

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorUniversity Hospital Heidelberg

About this trial

This study is a mixed-methods, single-arm cross-sectional study comprising 1) a qualitative, exploratory, critical-constructivist content analysis examining the significance of gender in relationship experiences and self-perception among individuals with borderline personality disorder and various gender identities, and 2) a pilot study on the use of the Single-Category Implicit Association Test (SC-IATs, adapted from von Hippel et al., 2018) as preparation for a larger-scale experimental psychological study using the SC-IAT to assess implicit gender- and BPD-related thought processes in people with borderline personality disorder and various gender identities.

15 individuals with BPD and different gender identities will be assessed. The research questions are:

1. What gender-related relationship- and self-experiences can be identified in people with BPD? How do experiences relate to observer-coded and self-reported mentalization ability, as well as self-reported symptoms, experiences of stigmatization, and quality of life? 2. Is there preliminary evidence that Single-Category Implicit Association Tests (SC-IATs) are suitable and reliable instruments for measuring implicit gender- and BPD-related thought processes in people with BPD?

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Signed informed consent form

Individuals of all genders (target: n=5 with female gender identity, n=5 with nonbinary/trans*/gender-non-conforming (TGNC) gender identity, n=5 with male gender identity) between the ages of 18 and 65 at the time of consent

Individuals with a BPD diagnosis made within the last 2 years (ICD-10: F60.3; DSM-5: 301.83, ICD-11: Borderline qualifier)

Understanding of the study procedure, ability and willingness to participate

Disqualifiers

Acute suicidal ideation or acute psychotic symptoms reported by the patient or suspected

Insufficient language skills (i.e., knowledge of German or English)

Trial population

The majority of recruitment takes place among participants in the study "Mentalization-based treatment versus bona-fide treatment for patients with Borderline Personality Disorder in Germany (MAGNET): a prospective, multi-center randomized controlled trial" (S-493/2023). Only those participants who indicated in the MAGNET study consent form that they consent to being contacted for further studies and have not withdrawn this consent will be contacted. In addition, individuals with diverse gender identities may be recruited through the Institute for Psychosocial Prevention and Psychotherapy at Heidelberg University Hospital using flyers (posted at the institute, on the website, and distributed during initial consultations)

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

15 Participants
are grouped into 1 trial group
Group A: Individuals with BPD and different gender identities

Trial outcomes

Primary outcomes

1

Role of Gender in BPD

Categories and themes derived from Grounded Theory qualitative content analysis of semi-structured interviews with individuals diagnosed with BPD, capturing experiences of gender in relation to self and interpersonal relationships including structural power dynamics

Time frame
At baseline
2

SC-IAT score

D-score derived from SC-IAT reaction times (ratio of mean reaction times between experimental blocks), reflecting the strength of implicit associations.

Time frame
At baseline
3

SC-IAT Stimulus Accuracy

Proportion of correct responses per stimulus and proportion of correct responses across all trials.

Time frame
At baseline
4

SC-IAT Internal Consistency

Internal consistency of each SC-IAT, assessed via split-half reliability or comparable coefficient.

Time frame
At baseline

Secondary outcomes

1

Correlations Between Qualitative Category Frequencies and Psychosocial Construct Scores

Descriptive Pearson or Spearman correlation coefficients between frequencies of qualitative content analysis categories and mean scores of the following self-report measures: Mentalizing Gender Experience Questionnaire (MGEQ), Certainty of Mental States Questionnaire (CAMSQ), Internalized Stigma of Mental Illness Scale 10-item Version (ISMI-10), Borderline Symptom List Short Version (BSL-23), Positive Mental Health Scale (PMH), European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-5L), Level of Personality Functioning Scale-Brief Form (LPFS-BF 2.0), Depression Anxiety Stress Scale-21 (DASS-21), Rosenberg Self-Esteem Scale Revised Version (RSE), Family Patriarchy Questionnaire (FPQ), and Epistemic Trust Mistrust and Credulity Questionnaire (ETMCQ).

Time frame
At baseline
2

SC-IAT Administration Duration

Time required to complete each SC-IAT, recorded in minutes and seconds.

Time frame
At baseline
3

SC-IAT Convergent Validity

Exploratory Pearson or Spearman correlation coefficients between SC-IAT D-scores and scores of MGEQ and ISMI.

Time frame
At baseline
4

SC-IAT Participant Acceptance

Qualitative feedback from participants regarding perceived feasibility, comprehensibility, and acceptability of the SC-IAT procedure.

Time frame
At baseline

Other outcomes

1

Mentalization Questionnaire

Mentalization Questionnaire (MZQ; Hausberg et al., 2012): The MZQ is a validated questionnaire designed to assess mentalization deficits. It consists of a total of 15 items across four scales associated with mentalization: emotional awareness, affect regulation, psychological equivalence mode, and negative self-reflection. The items (e.g., "I often have no idea what is going on inside me") are rated on a 5-point scale ranging from (1) "strongly disagree" to (5) "strongly agree." A high total score indicates low mentalizing ability.

Time frame
At baseline
2

Mentalizing Gender Experience Questionnaire

Mentalizing Gender Experience Questionnaire (Hauschild et al., in prep): The MGEQ was developed based on the Mentalizing Emotions Questionnaire (Kasper et al., 2024) and is currently being evaluated in a validation study (Hauschild et al., in prep.). The questions relate to the experiences of individuals with a specific gender identity (including agender) and encompass thoughts, feelings, and beliefs as well as (physical) sensations that individuals associate with their gender. In total, the MGEQ comprises 8 items (e.g., "I find it helpful to reflect on the reasons why others experience themselves as a woman/man/non-binary person/self-designation.") on the Self and Others subscales, and are rated on a 7-point Likert scale ranging from (1) "never" to (7) "always." Higher scores indicate a better understanding of aspects of gender identity in oneself and others, as well as the ability to communicate these aspects.

Time frame
At baseline
3

Certainty of Mental States Questionnaire

Certainty of Mental States Questionnaire (CAMSQ; Müller et al., 2023): The CAMSQ is a self-assessment tool in which participants evaluate their own mental states and those of others. The questionnaire consists of a total of 20 items (e.g., "I am aware of my deepest desires and longings."), which are answered on a 7-point scale ranging from (1) "never" to (7) "always" to measure participants' understanding of their own feelings and their perception of others. The results are divided into two main categories: self-confidence and confidence in others.

Time frame
At baseline
4

Internalized Stigma of Mental Illness Scale 10-item Version

Internalized Stigma of Mental Illness Scale 10-item Version (ISMI-10; Boyd et al., 2014): The ISMI measures experiences of stigma related to mental disorders. In the present study, the ISMI was specifically adapted to assess experiences of stigma associated with borderline personality disorder. The short scale comprises a total of 10 items (e.g., "I cannot contribute anything to society because I have borderline personality disorder") and is rated on a 4-point Likert scale ranging from (1) "strongly disagree" to (4) "strongly agree."

Time frame
At baseline

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