The Role of Histamine in Muscle Protein Synthesis Following Resistance Training
ConditionHistamine
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-45
SponsorUniversity Ghent
About this trial
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male
18-45 years
Not to medium physically active
Disqualifiers
Smoking
Chronic disease
High blood pressure
Supplement or medication intake
Trial design
Design model
Parallel
Treatments tested in this trial
Placebo
DrugOral placebo
H1 blockade: Telfast: 180mg Fexofenadine
DrugH1 blockade: oral blockade with 180mg Fexofenadine
Resistance training
BehavioralResistance training: lower body exercise
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: 1: PlaceboPlacebo comparator 2 interventions
Group B: H1 blockade: Telfast (180mg Fexofenadine)Experimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Muscle volume
Change in muscle volume
Time frame
Before and after the 10 weeks of resistance training2
Maximal dynamic strength of leg press, bench press, bicep curl and leg curl
Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl
Time frame
Before and after the 10 weeks of resistance training3
Muscle fiber hypertrophy in muscle biopsies
Change in muscle fiber hypertrophy in muscle biopsies
Time frame
Before and after the 10 weeks of resistance training4
Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)
Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)
Time frame
Before and after the 10 weeks of resistance trainingSecondary outcomes
1
Blood pressure (systolic and diastolic)
Chance in Blood pressure (systolic and diastolic)
Time frame
Before and after the 10 weeks of resistance training2
Resting heart rate
Chance in Resting heart rate
Time frame
Before and after the 10 weeks of resistance trainingSponsors and contacts
Click on the lead sponsor to view all of their trials.
University Ghent
Lead sponsor
Research Foundation Flanders
Collaborator
Source ClinicalTrials.gov