The Role of Oxytocin in Regulating Blood Glucose
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age20-50
SponsorUniversity Hospital, Gentofte, Copenhagen
About this trial
Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
BMI 19-25 kg/m2
Disqualifiers
Diabetes
Heart-, liver or kidney disease
More than 14 units of alcohol weekly, or drug abuse
Smoking or any kind of nicotine products
Trial design
Design model
Crossover
Treatments tested in this trial
Oxytocin
DrugOxytocin
Placebo
Other interventionSaline
Treatment groups
20 Participants
are divided into 3 treatment groupsGroup A: PlaceboPlacebo comparator 1 intervention
Group B: Oxytocin 0.1 IU/minExperimental treatment 1 intervention
Group C: Oxytocin 0.2 IU/minExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Insulin secretion - c-peptide
Insulin secretion, measured as percentual increase of area under the curve (AUC) for circulating c-peptide
Time frame
From time 0 to time 180 minSecondary outcomes
1
Glucose
measured as percentual increase of AUC for circulating levels
Time frame
From time 0 minutes to time 180 minutes2
Insulin
measured as percentual increase of AUC for circulating levels
Time frame
From time 0 minutes to time 180 minutes3
Glucagon
measured as percentual increase of AUC for circulating levels
Time frame
From time 0 minutes to time 180 minutes4
GIP
measured as percentual increase of AUC for circulating levels
Time frame
From time 0 minutes to time 180 minutesSponsors and contacts
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Source ClinicalTrials.gov