The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-25
SponsorUniversity of North Carolina, Greensboro

About this trial

Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and/or arousal-based effects of exercise on memory could be differed by the time of day in young adults based on their circadian rhythms of HRV. Moreover, young adults prefer afternoon or evening to morning in their circadian rhythms, demonstrating less wakefulness and lower memory performance in the morning relative to afternoon. Based on the potential psychophysiological mechanisms, exercise could impact young adults' memory differently by the time of day. The investigators aim to 1) determine the extent to which the time of day modulates how moderate-intensity cardiovascular exercise impacts verbal-auditory and visuospatial short- and long-term memory in young adults, and 2) consider potential psychological and physiological markers that may mediate exercise's effects on cognitive performance. As cognitive benefits of exercise might differ by the time of day, it is important to investigate such interaction and make the right recommendations of the timing of exercise for young adults in academic settings.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Between the ages of 18-25.

Currently meeting the American College of Sports Medicine's recommended guidelines of activity (at least 90 min/week of moderate and/or vigorous physical activity).

Willing to participate for 4 days (2 visits) and refrain from exercise outside of the lab for 4 days (1 day before and the day of two visits).

Disqualifiers

Any known history of cardiac, pulmonary, or metabolic disease (e.g. cardiovascular disease, asthma, diabetes).

A current musculoskeletal injury, mental illness (e.g., depression, anxiety, or stress disorders), or sleep disorder.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Moderate-intensity aerobic exercise

    Behavioral

    Eligible participants will come into the lab on day 1 and 3 at the same time of day (either morning at 7-10am or afternoon at 3-5pm). They will be then randomly assigned for a rest or an exercise session prior to the memory test. For the rest condition, they will be required to sit and relax while watching Planet Earth for 30 minutes on a cycle ergometer. During the exercise session, they will complete a moderate-intensity cardiovascular exercise for 20 minutes following a 5-min warm-up and followed by a 5-min cool-down on a cycle ergometer. They will start the memory test immediately after the rest/exercise session.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Morning groupExperimental treatment 1 intervention
Group B: Afternoon groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Verbal episodic memory change

Verbal episodic memory will be assessed immediately and 24 hour after intervention (rest and exercise) using the Auditory Verbal Learning Test (AVLT trial 1 - 8; max/min score: 15/0 for each trial)

Time frame
Immediately after the intervention, the first cognitive test
2

Visual episodic memory change

Verbal episodic memory will be assessed immediately after intervention (rest and exercise) using the NIH Toolbox Picture Sequence Memory Test (max/min score: 30/0).

Time frame
Immediately after the intervention, the second cognitive test
3

Lure discrimination index change

Lure discrimination index will be assessed immediately after intervention (rest and exercise) using the Mnemonic Similarity Task (max/min score: 1/0).

Time frame
Immediately after the intervention, the third cognitive test
4

Working memory change

Verbal episodic memory will be assessed immediately after intervention (rest and exercise) using the Digits Span Forward and Backward Task (max/min score: 14/0).

Time frame
Immediately after the intervention, the fourth cognitive test

Secondary outcomes

Other outcomes

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