The SAVOR Study: Appetite and Physiological Responses
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age65-74
SponsorSingapore Institute of Food and Biotechnology Innovation
About this trial
The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline. The investigators hypothesize that seniors experiencing appetite decline will exhibit distinct oro-sensory, gastrointestinal, and hormonal profiles compared to seniors with healthy appetites, suggesting underlying biological mechanisms contributing to reduced appetite.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Postmenopausal female
Aged 65-74 years
Habitual breakfast consumer (consumes breakfast between 7am to 10am)
Willingness to consume meals and follow intervention protocol
Disqualifiers
BMI ≥ 27.5
Diagnosed with medical condition that may influence appetite or microbiome (e.g. diabetes, thyroid disorders, gastrointestinal diseases)
Currently taking any medications or supplements that may influence appetite or the microbiome (e.g. probiotics, antibiotics, appetite stimulants/suppressants) one month prior to their first visit in consultation with study physician, PI and study team
Following a special diet for weight management (e.g. low-calorie, low carbohydrate)
Trial design
Design model
Single group
Treatments tested in this trial
Shredded Chicken Congee
Other interventionThis is a mixed meal tolerance test intended to elicit gut hormone responses reflective of real-world dietary patterns.
Treatment groups
20 Participants
are divided into 1 treatment groupGroup A: Chicken porridgeExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Ad Libitum Lunch
Participants will be asked to eat as much of the stir-fried beehoon as they want until they are comfortably full, to measure the exact calorie intake by weighing the food before and after eating.
Time frame
Participants will be given 30 minutes to consume the meal until they are comfortably full, 180 minutes after the start of the intervention.Secondary outcomes
1
Palatability questionnaire
Palatability appetite questionnaire, rated on a visual analogue scale is a psychometric assessment tool where participants rate their subjective sensory experience-such as taste, smell, or pleasantness-by marking a point along a continuous 100 mm line anchored by opposing extremes (e.g., "extremely unpleasant" to "extremely pleasant").
Time frame
Administered after consuming test meal and after consuming the ad libitum meal.2
Appetite hormones
GLP-1, PYY and Acyl-ghrelin will be used to measure hormones related to appetite.
Time frame
Blood samples will be collected at timepoints (t = -15 minute (baseline), 30, 60, 90, 120 and 180 minutes)3
Subjective Appetite Questionnaire
A subjective appetite questionnaire utilizes a Visual Analogue Scale to quantify a person's current metabolic state by measuring four key sensations: hunger, fullness, desire to eat, and prospective food consumption.
Time frame
Measurement is taken at t = -15 minute (baseline), 10, 30, 60, 90, 120 and 180 minutes4
Gastric Ultrasound
Gastric ultrasound will measure the gastric emptying rate postprandially.
Time frame
Measurements will be taken at t = -15 minute (baseline), 15, 45, 105 and 165 minutesOther outcomes
1
Health and Lifestyle questionnaire
This questionnaire is to evaluate the participant's eligibility for the study. It consist of participant information, medical and health history, lifestyle and diet, physical activity.
Time frame
Baseline measurement that is completed during screening visit2
3-day food record
A 3-day food record is a detailed diary where participants document everything they eat and drink over two weekdays and one weekend day to provide an accurate snapshot of their typical nutritional intake. This is done using household measures (or digital scales), where exact portion sizes, cooking methods and brand names of all items are used.
Time frame
Administered between screening and actual test session, to be completed on 2 weekdays and 1 weekend.3
Gastrointestinal Symptom Rating Scale (GSRS)
The Gastrointestinal Symptom Rating Scale (GSRS) is a validated 15-item questionnaire used to assess the presence and severity of common digestive issues across five key areas: abdominal pain, reflux, diarrhea, constipation, and indigestion. Participants rate each symptom on a 7-point Likert scale-ranging from "no discomfort" to "very severe discomfort"-to provide a quantifiable measurement of their gastrointestinal well-being.
Time frame
Baseline measurement administered once during screening.4
Council on Nutrition Appetite Questionnaire (CNAQ)
The Council on Nutrition Appetite Questionnaire (CNAQ) is a brief, 8-item screening tool designed to predict future weight loss by assessing a participant's appetite and dietary habits. It asks about sensations like hunger, how quickly a participant feel full, and how food tastes to determine if a participant is at risk for nutritional deficiencies or significant weight changes over the coming months.
Time frame
Baseline measurement administered once during screening, takes approximately 5-10 minutesSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: