The Significance of Release of T-follicular Helper and T-follicular Regulatory Cells in Autoimmune Haemolytic Anemia Before and After Tratment

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorAssiut University

About this trial

we study the circulating T-follicular regulatory and T-follicular regulatory cells in autoimmune hemolytic anemia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients diagnosed as autoimmune hemolytic anemia, primary or secondary, male or female, any age but not on treatment

Disqualifiers

Pregnancy or breast-feeding women

Patients treated with corticoids or immunosuppressant.

Patients with hematological malignance.

Patients with alloimmune hemolytic anemia as ABO incompatibility or transplant patients

Trial population

The sample size is 50 (25 in each arm) but number of controls will be decreased and number of cases will be increased

Trial design

Design model

Case-control

Time perspective

Retrospective

Treatments tested in this trial

  • flowcytometry

    Diagnostic test

    The study of CD4,CD25,FOXP3 and PD-1 on peripheral blood sample

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

The proportion of circulating T-follicular helper and T-follicular regulatory in patients with Autoimmune Hemolytic Anemia (AIHA), at diagnosis and after treatment

Time frame
Baseline

Secondary outcomes

1

Measure the ratio between the T- follicular helper and T-follicular regulatory

Time frame
Baseline

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

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