Health TrialsbyHealthPanel

The Spiral MRI Study

ConditionBrain MRI
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Wisconsin, Madison

About this trial

The goal of this clinical trial is to find out if new Magnetic Resonance Imaging (MRI) computer software will:

* help make scans and exams faster * reduce artifacts * make MRI easier to understand * allow technicians to focus more on the participant and less on the scanner

Participants will complete one brain MRI imaging session, lasting about 60 minutes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults at least 18 years

Able to provide written informed consent on their own behalf

Adults at least 18 years

Able to provide written informed consent on their own behalf

Disqualifiers

Unable or unwilling to provide informed consent

Contraindication(s) to or inability to undergo MRI

Currently pregnant

participant has their own prescription for the medication

Trial design

Design model

Parallel

Treatments tested in this trial

  • Brain MRI

    Device

    90 participants will undergo a 60 minute SOC brain MRI followed by 15 minute spiral MRI

  • Brain MRI - SOC and spiral

    Device

    6 participants will be scanned using 2 versions (SOC and spiral) pf 6 sequences (12 scans total).

  • Brain MRI - spiral

    Device

    10 participants will be scanned with 3 sequences, 3 times (9 total scans per participants)

  • Brain MRI - SOC and spiral

    Device

    10 participants will be scanned using 2 versions (SOC and spiral) of 6 sequences (12 scans total).

  • Brain MRI - spiral

    Device

    10 participants will be scanned with 3 spiral sequences to achieve desired signal to noise ratio (SNR).

  • Brain MRI - spiral

    Device

    5 participants will be scanned with 2 pairs of 6 spiral sequences.

Treatment groups

131 Participants
are divided into 6 treatment groups

6

Treatment groups

See each treatment group below.

Group A: Healthy Participants - Scan EfficiencyExperimental treatment 1 intervention
Group B: Standard of Care (SOC) Brain MRIActive comparator 1 intervention
Group C: Healthy Participants - TauExperimental treatment 1 intervention
Group D: Healthy Participants - image qualityExperimental treatment 1 intervention
Group E: Healthy Participants - SNRExperimental treatment 1 intervention
Group F: Healthy Participants - Gradient DeratingExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Image quality - decreasing scan time

Participants will be scanned using 2 versions (standard and spiral) of 6 sequences (12 scans total). For each sequence pair, scan time will be sped up. Image quality will be compared between the 2 versions.

Time frame
60 minutes
2

Image quality - tau

Measuring whether image quality is sufficient for routine diagnostic interpretation - specifically robustness to artifacts. The independent variable is a scanning parameter called tau, which researchers want to be long (because it makes the total scan time shorter). Researchers will compare the value of tau between SOC imaging and spiral. They will use a 5-point Likert scale to compare, where 1= undiagnostic (unacceptable), 2 = spiral scans slightly worse than SOC but acceptable, 3= spiral scans same as SOC (acceptable), 4= spiral scans slightly better than SOC (acceptable), 5=spiral scans much better than SOC (acceptable).

Time frame
60 minutes
3

Image quality - consistent scan time

Participants will be scanned using 2 versions (standard and designed) of 6 sequences (12 scans total). Scan time will remain the same for each pair. Radiologists will compare each pair for differences in image quality using a 5-point Likert scale where 1= A much worse than B, 2=A slightly worse than B, 3=A comparable to B, 4=A slightly better than B, 5=A much better than B. A=new spiral scans and B=SOC scans.

Time frame
60 minutes
4

Signal to Noise Ratio (SNR)

Measuring the SNR in images, by measuring the signal strength in the image and the calculated noise in those images and taking the ratio. Researchers will compare this SNR to that which their methods predicted.

Time frame
60 minutes

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Wisconsin, Madison

Lead sponsor

National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: