The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorZhujiang Hospital

About this trial

Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain activity of lower urinary tract function in neobladder patients is still unclear.The aim of this study is to explore the brain activity of urination intention and self-controlled urination behavior in patients with orthotopic sigmoid neobladder by task-state functional magnetic resonance imaging (fMRI).

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Being right-handed;

3 months or more after operation;

No contraindications to fMIR examination;

Voluntarily sign informed consent.

Disqualifiers

History of bladder radiotherapy;

History of prostate cancer;

Suffering from diseases affecting abdominal pressure;

History of abnormal brain anatomy, craniocerebral surgery, craniocerebral tumor, and craniocerebral radiotherapy;

Trial population

Patients 3 months or more after orthotopic neobladder surgery.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

40 Participants
are grouped into 1 trial group
Group A: Patients with orthotopic neobladder

Trial outcomes

Primary outcomes

1

The location of brain functional activation areas

Areas of the brain where excitation or inhibition occurs in fMRI images

Time frame
3 months
2

The peak T-value size of the activation region

Peak T values of activated or inhibited regions of the brain in fMRI images

Time frame
3 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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