The presented project aims to characterize the microbiome of healthy peri- and postmenopausal women and its correlation with the metabolome of urine and serum.
Women over 50 years old
Consent to participate in the study
Willingness to take urine and blood samples according to the protocol
Known congenital developmental defects of the urinary tract (congenital hydronephrosis, vesicoureteral reflux, renal agenesis, and hypoplasia, multicystic and polycystic kidneys)
Recurrent urinary tract infections (more than 3 episodes in the last 12 months)
Presence of any lower-urinary tract symptoms (urgency, frequency, incontinence, stranguria, urge to urinate, weak urine stream, the feeling of post-micturition residue)
The presence of a foreign body in the urinary tract - urolithiasis, urinary catheter, ureteral stent
Healthy peri- and post-menopausal female volunteers.
Case-only
Prospective
Blood and urine sample evaluation
Diagnostic testBlood and urine sample evaluation will be performed in healthy female volunteers.
Microbiome alpha-diversity
The number of bacterial species in the urine sample will be assessed.
Microbiome beta-diversity
Inter-individual variability in the proportion of bacterial species will be assessed.
Correlation of microbiome alpha-diversity and serum metabolome
The correlation of microbiome alpha-diversity and serum metabolome will be assessed.
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