The objectives of this research are to determine the treatment effect size of OMM to wean patients off of the ventilator, determine the number of patients needed for a larger study (power), determine the willingness of patients/POAs to be recruited, identify the correct dosing of OMM and whether there are concerns for the safety of treatment, and determine whether the hypothesis is feasible for a larger study. The primary outcome measure is the duration of time until a subject is weaned off of mechanical ventilation using Osteopathic Manipulative Medicine (OMM). The secondary outcome measures (see the next section for further explanation) are to determine if OMM affects changes in morbidity and mortality, such as VBG/ABG, NIF, RSBI, P 0.1, FiO2, PEEP, mental status, hemodynamic stability (blood pressure), spontaneous TV, reintubation after extubation, and death.
Acute respiratory failure (hypoxic, hypercapnic, or neuromuscular)
Not making satisfactory progress with weaning after being on the ventilator for more than 48 hours
Clinical stability for pressure support trial with ventilator to monitor ventilation progression
Pulmonology must be following the patient for standardized ventilator management approach and interventions as needed
Age less than 18 years old or more than 85 years old
BMI>60
Moderate/severe neurological disease with expectation of non-progression off the ventilator or poor quality of life predicted (including end-stage dementia with the expectation of non-progression off ventilator, multiple sclerosis, ALS, anoxic brain injury, etc)
Status epilepticus or EEG result pending
Parallel
Osteopathic Manipulative Treatment
Procedure/SurgerySee treatment arm
Time on ventilator
Number of days that the patient is on the ventilator after inclusion in the study
Ventilator associated measurement
VBG/ABG
Ventilator associated measurement
Negative inspiratory force (NIF)
Ventilator associated measurement
Rapid Shallow Breathing Index (RSBI)
Ventilator associated measurement
Airway occlusion pressure (P0.1)
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
