The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNational Taiwan University Hospital

About this trial

Objectives/Hypotheses

1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate. 2. Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation / ventricular tachycardia; VF/VT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules. 3. We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules. 4. We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

out of hospital cardiac arrest (OHCA) patients

Disqualifiers

age <18 years

non-EMS transport to the emergency department

obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders

missing data despite meeting the inclusion criteria.

Trial population

The study population included adults, OHCA patients since1 January 2007, identified from the PAROS registry. The PAROS data encompass 13 countries. The exclusion criteria include: (1) age \<18 years, (2) non-EMS transport to the emergency department, (3) obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders, and (4) missing data despite meeting the inclusion criteria.

Trial design

Design model

Other

Time perspective

Other

Treatments tested in this trial

  • termination of resuscitation rules

    Other intervention

    Use retrospective data to analyze the accuracy termination of resuscitation rules and further develope a termination of resuscitation rule.

Treatment groups

140,000 Participants
are divided into 1 treatment group
Group A: out of hospital cardiac arrest patients in Asia countries1 intervention

Trial outcomes

Primary outcomes

1

survival to hospital discharge

survival to 30-day hospitalisation

Time frame
survival to 30-day hospitalisation

Secondary outcomes

1

Cerebral Performance Categories Scale (CPC)

CPC Scale 1\~5, minimum value: 1; maximum value:5; lower score means greater outcome

Time frame
CPC within 30-day hospitalisation

Other outcomes

Sponsors and contacts

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National Taiwan University Hospital

Lead sponsor

Singapore Clinical Research Institute

Collaborator