The Ventilation During In-hospital Cardiac Arrest Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Aarhus
About this trial
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.
The main questions it aims to answer are:
What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?
Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
In-hospital cardiac arrest
Age ≥ 18 years
>1minute of recorded ventilation data
Disqualifiers
Documented do-not-attempt cardiopulmonary resuscitation order
Invasive mechanical circulatory support at the time of the cardiac arrest
Trial population
Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Positive pressure ventilation during cardiopulmonary resuscitation
Other interventionThe primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.
Treatment groups
900 Participants
are divided into 1 treatment groupGroup A: Study cohort1 intervention
Trial outcomes
Primary outcomes
1
Fraction of patients with return of spontaneous circulation (ROSC)
ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.
Time frame
ROSC is assessed immediately following cardiopulmonary resuscitation.Secondary outcomes
1
Fraction of patients surviving until day 30
Patient survival for at least 30 days following cardiac arrest.
Time frame
Assessed at day 30 after cardiac arrest.Other outcomes
1
Fraction of patients with pulmonary complications
Composite endpoint of pulmonary complications after return of spontaneous circulation (ROSC) including acute respiratory distress syndrome (ARDS), aspiration, pneumothorax and hemothorax.
Time frame
From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.2
Number of days alive without mechanical ventilation
Days patients are alive without receiving mechanical ventilation after return of spontaneous circulation (ROSC).
Time frame
From date of ROSC until day 30 or date of death from any cause, whichever came first.3
Number of days alive outside the intensive care unit
Days patients are alive outside of the intensive care unit after return of spontaneous circulation (ROSC).
Time frame
From date of ROSC until day 90 or date of death from any cause, whichever came first.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov