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Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients

ConditionVentilator-Induced Diaphragmatic Dysfunction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-90
SponsorSouth Valley University

About this trial

The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients who had undergone MV for 48 hours or more in a controlled mode.

Patients could not generate maximum inspiratory pressure of more than 15 mbar

Patients had diaphragmatic excursion less than 3 cm. (normal level from 3 to 5 cm.)(It can increase in a condition person to 7-8 cm).

Patients had a diaphragmatic thickness fraction of less than 30%

Disqualifiers

Patients with comorbidities interfering and compromising weaning like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome.

Patients who had inadequate training performance of the inspiratory muscle such as those having myopathy or neuropathy.

Patients hemodynamically unstable.

Patients who had a major neurological deficit.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.

    Device

    All patients were investigated by routine investigation (vital signs, arterial blood gas, ventilator mode, and the parameters). Two sessions were implemented per day for the study group for one week. The Trigger sensitivity adjustment trial begins with applying a load of 30% of the first recorded Negative Inspiratory Force (NIF). 1. st Day 1st session, 30% 5 min. 2. nd session, 30% 10 min. 2nd Day 1st session, 30% 15 min 2nd session, 30% 20 min. 3rd Day 1st session, 30% 25 min. 2nd session, 30% 30 min. 4th Day 1st session, 40% 5 min. 2nd session, 40% 10 min. 5th Day 1st session 40% 15 min 2nd session 40% 20 min. 6th Day 1st session 40% 25 min. 2nd session 40% 30 min. 7th Day 1st session 50% 5 min. 2nd session 50% 10 min.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Study groupExperimental treatment 1 intervention
Group B: Controlled groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Vital signs

Heart Rate (HR) b/min

Time frame
one week
2

Respiratory rate RR/min

Respiratory rate RR/min

Time frame
one week
3

Blood Pressure mmHg

Blood Pressure mmHg

Time frame
one week
4

Arterial blood gases (ABG):-

PH

Time frame
one week

Secondary outcomes

1

Ventilator parameters

Minute Ventilation L/min

Time frame
one week
2

Tidal Volume L/breath

Tidal Volume L/breath

Time frame
one week

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

South Valley University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: