This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy evaluation and prognostic prediction of the LVO patients with low NIHSS.
Aged 18 years or older
Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset
Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel
Baseline ASPECTS ≥6 or infarct Core Volume of < 70 on NCCT/DWI/CTP
Any sign of intracranial hemorrhage on baseline CT/MR;
Seizures at stroke onset
Baseline blood glucose of <2.78 mmol or >22.20 mmol, or platelet count < 100,000/uL or serum creatinine levels > 3.0 mg/dL
Participation in any investigational study in the previous 30 days
Acute ischemic stroke patients with minor stroke (NIHSS 0-5) and large artery occlusion.
Cohort
Prospective
Immediate endovascular therapy
Other interventionThe best medical therapy includes intravenous fibrinolysis, anticoagulants or antiplatelet, but NOT any immediate endovascular therapies.
modified Rankin Scale at 90 days
modified Rankin Scale at 90 days
acute neurological deterioration
It is neurological deterioration of presumed ischemic origin with an NIHSS score increase of 4 points or more within the 24 hours after onset.
Incidence of symptomatic intracerebral hemorrhage
Incidence of symptomatic intracerebral hemorrhage according to ECASS II criteria
patients with good outcome comparing the two treatment groups
Good outcome is defined as a score of 0-2 on the 90-day mRS
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