Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondation Ophtalmologique Adolphe de Rothschild
About this trial
The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,
A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,
An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission >4.
For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.
Disqualifiers
Pre-existing functional and/or cognitive disability
Patient under legal protection.
Pregnant or breastfeeding woman.
Patient with secondary haemorrhagic transformation.
Trial population
Patients treated at the Rothschild Foundation Hospital within the first 24 hours of an acute neurological symptomatology
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Blood sampling
Other interventionBlood sampling will be made to Day 0, Day 3 and to 3 month after inclusion
Treatment groups
200 Participants
are divided into 2 treatment groupsGroup A: Case1 intervention
Group B: Control1 intervention
Trial outcomes
Primary outcomes
1
Biomarker rates at day 0
Biomarker: Neutro-Plaket aggregates, extra-cellular DNA networks, von Willebrand Factor
Time frame
24 hoursSponsors and contacts
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Source ClinicalTrials.gov