The goal of this clinical trial is to learn about the effects of time-restricted eating in patients with history of acute coronary syndrome. The main questions it aims to answer are: 1) Is 10-hr TRE safe and feasible for patients with ACS; 2)What are the impacts of 10-hr TRE on anthropometric measurements, cardiometabolic health and cardiovascular health compared to ad libitum eating in patients with ACS?. Participants will be asked to limit eating duration to 10 hours daily.
Adult, 18- 65 years old.
Had history of acute coronary syndrome (ACS)
Clinically stable
Self-reported eating window of at least 12 h per day.
Severe obesity (body mass index ≥40 kg m-2).
Unstable weight in the past three months (gain or lose more than 4 kg of weight).
Unstable cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that may compromise study validity.
Any medications or supplements known to change sleep, circadian rhythms, or metabolism.
Parallel
Time-restricted eating 10-hr
BehavioralTime-restricted eating is a form of intermittent fasting. In this study, 10-hr TRE will be employed, where eating duration is limited to 10 hours. Participants are allowed to consume non-caloric beverages during fasting period.
Change in weight
unit: kg
Change in lean body mass
unit : kg
Change in fat mass
unit : kg
Change in fasting glucose concentration
Glycaemic biomarker, unit: mmol/L
Change in fasting insulin concentration
Glycaemic biomarker, unit:pmol/L
Rate of weekly compliance to intervention
Adherence to intervention, number of days complied to eating duration assigned/ 7 daysx100%
Change in caloric intake
Dietary energy consumption, unit: kcal/day
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Universiti Teknologi Mara
Lead sponsor
Ministry of Higher Education, Malaysia
Collaborator
