Timing of Endoscopy in Cirrhotic Patients with Acute Variceal Bleeding
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorGeneral Hospital of Shenyang Military Region
About this trial
Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in patients with liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of timing of endoscopy on the outcomes of cirrhotic patients with AVB.
Eligibility criteria
Qualifiers
patients with AUGIB which is highly suspected to be caused by gastroesophageal variceal rupture;
patients with a diagnosis of liver cirrhosis based on imaging and pathology;
patients and/or their relatives who sign informed consents;
patients' age ≥18 years.
Disqualifiers
patients who have undergone endoscopy at other hospitals before admissions;
patients' hemodynamics are unstable after resuscitation;
patients with severe cardiovascular or cerebrovascular diseases or renal injury;
patients who have taken anticoagulants or antiplatelet drugs within 2 weeks before admissions, or are diagnosed with severe hematological diseases;
Trial design
Treatments tested in this trial
- Endoscopy
Treatment groups
368 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov